AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). AS-605240 displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα.
AS-605240|AS605240; AS 605240|CAS 648450-29-7 Buy AS-605240 from supplier medchemexpress.com
AMG-337|AMG337;AMG 337|CAS 1173699-31-4 Buy AMG-337 from supplier medchemexpress.com
AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays....Quality confirmed by NMR,HPLC & MS.
PIM-447 dihydrochloride|CAS 1820565-69-2 Buy PIM-447 dihydrochloride from supplier medchemexpress.com
PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase....Quality confirmed by NMR,HPLC & MS.
AZD2014|Vistusertib;AZD-2014|CAS 1009298-59-2 Buy AZD2014 from supplier medchemexpress.com
AZD2014 is a novel mTOR inhibitor with IC50 of 2.8 nM; highly selective against multiple PI3K isoforms (α/β/γ/δ).
TIC10|TIC-10;ONC-201|CAS 1616632-77-9 Buy TIC10 from supplier medchemexpress.com
TIC10(ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier....Quality confirmed by NMR,HPLC & MS.
Quisinostat|JNJ-26481585|CAS 875320-29-9 Buy Quisinostat from supplier medchemexpress.com
Quisinostat is an orally available, potent, hydroxamate, pan-HDACi with broad activity in solid and hematologic tumor models. Quisinostat inhibits HDAC1 (IC50 = 0.11 nM), HDAC2 (IC50 = 0.33 nM), HDAC4 (IC50 = 0.64 nM), HDAC10 (IC50 = 0.46 nM), HDAC11 (IC50 = 0.37 nM).
...Quality confirmed by NMR,HPLC & MS.
...Quality confirmed by NMR,HPLC & MS.
SHP099|SHP 099;SHP-099|CAS 1801747-42-1 Buy SHP099 from supplier medchemexpress.com
SHP099 is a selective and orally bioavailable small-molecule SHP2 inhibitor with IC50 of 0.071 μM.
...Quality confirmed by NMR,HPLC & MS.
...Quality confirmed by NMR,HPLC & MS.
AZD6738|AZD-6738|CAS 1352226-88-0 Buy AZD6738 from supplier medchemexpress.com
AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells....Quality confirmed by NMR,HPLC & MS.
Talarozole|R115866;R-115866;R 115866|CAS 201410-53-9 Buy Talarozole from supplier medchemexpress.com
Talarozole(R115866) is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.
HG-9-91-01|SIK inhibitor 1|CAS 1456858-58-4 Buy HG-9-91-01 from supplier medchemexpress.com
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.